• Administration of tetradecylthioacetic acid (TTA) stimulates myocardial fatty acid oxidation despite having a lipid-lowering effect 

      Severson, DL; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Clarke, Kieran; Hagve, Martin; Berge, Rolf; Lund, trine; Larsen, Terje; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)
    • The Ambivalence of Connexin43 Gap Peptides in Cardioprotection of the Isolated Heart against Ischemic Injury 

      Falck, Aleksander Tank; Lund, Bjarte Aarmo; Johansen, David; Lund, trine; Ytrehus, Kirsti (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-05)
      The present study investigates infarct-reducing effects of blocking ischemia-induced opening of connexin43 hemichannels using peptides Gap19, Gap26 or Gap27. Cardioprotection by ischemic preconditioning (IPC) and Gap peptides was compared, and combined treatment was tested in isolated, perfused male rat hearts using function and infarct size after global ischemia, high-resolution respirometry of ...
    • Gene Expression, Function and Ischemia Tolerance in Male and Female Rat Hearts After Sub-Toxic Levels of Angiotensin II 

      Aljabri, Mohammad Belal; Lund, trine; Høper, Anje Christina; Andreasen, thomas vennØ; Al-Saad, Samer; Lindal, Sigurd; Ytrehus, Kirsti (Journal article; Tidsskriftartikkel; Peer reviewed, 2010-12-19)
      To examine the response to chronic high-dose angiotensin II (Ang II) and a proposed milder response in female hearts with respect to gene expression and ischemic injury. Female and male litter–matched rats were treated with 400 ng kg<sup>-1</sup> min<sup>-1</sup> Ang II for 14 days. Hearts were isolated, subjected to 30-min ischemia and 30-min reperfusion in combination with functional monitoring ...
    • High-resolution visualization and assessment of basal and OXPHOS-induced mitophagy in H9c2 cardiomyoblasts 

      Godtliebsen, Gustav; Larsen, Kenneth Bowitz; Bhujabal, Zambarlal Babanrao; Opstad, Ida Sundvor; Nager Grifo, Mireia; Punnakkal, Abhinanda Ranjit; Kalstad, Trine; Olsen, Randi; Lund, trine; Prasad, Dilip K.; Agarwal, Krishna; Myrmel, Truls; Birgisdottir, Åsa birna (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-05)
      Mitochondria are susceptible to damage resulting from their activity as energy providers. Damaged mitochondria can cause harm to the cell and thus mitochondria are subjected to elaborate quality-control mechanisms including elimination via lysosomal degradation in a process termed mitophagy. Basal mitophagy is a house-keeping mechanism fine-tuning the number of mitochondria according to the metabolic ...